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ProtGPT2

ProtGPT2 is a transformer-based language model designed for generating and predicting protein sequences. Leveraging vast datasets of protein sequences, it can suggest sequences that align with desired functions, enhance stability, and facilitate novel protein designs. This model plays a crucial role in protein engineering, enabling applications in drug discovery, enzyme optimization, and the development of therapeutic proteins.

Create 3 proteins

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Inputs for ProtGPT2 Sequence Generation:

Amino Acid Sequence:

The initial amino acid sequence provided in standard formats, such as FASTA, serving as a basis for generating variations or new sequences.

Contextual Information for Protein Design

Optional metadata that includes details about the protein’s intended function or specific design constraints that guide the generation process.

Properties for Optimizing Protein Sequences

Specifications regarding the characteristics to be optimized, such as stability, activity, or binding affinities, which influence the output sequence.

Outputs from ProtGPT2 for Protein Function Prediction:

Generated Protein Sequence Variants

The predicted amino acid sequence generated by ProtGPT2, reflecting modifications or new designs based on the input parameters and desired properties.

Predicted Functions for Designed Proteins

A list of potential functions associated with the generated sequence, providing insights into the biological roles the protein may fulfill.

Confidence Scores for Sequence Reliability

Metrics that indicate the reliability of the generated sequences and their predicted functions, aiding researchers in prioritizing candidates for further investigation.

Examples of ProtGPT2 Applications