MXM4I

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

499 AAs
MPTYTVTVATGSQWFAGTYDSIYLTLVGERGSESKQLLDRPFYDDFERGAVDYDVQCPEDLGDLILVKLKHKKWFPRDDWYCQYITVTRPDGSYVEFPCYRWIQGDEIVELREGRARLTDSDQLPLLQKHRRQELERRQRNYRWSQWIPGFPMAIDSCHLDKLPRDIRFDETGNFDYTLYSNAALNRMNIMFLFMQSWSDWDDFEKIFPKWKTTMSEYVNEHWQSDDFFGFQYLNGCNPMVLQRCTSLPEKFPVTDTMVQNALETGELTLQEELERGNIFLADYDLLDGIPNAKVDIGCQQYLAAPICLLKYNPQNKLPMIAIQLQNPPGPENPIFLPTDSKYDWLLAKTWVRNSDFQLHQQITHLLRTHLIAEVFAVAMCRQLPCLHPVFKLLIPHTRYTIEINITARQNLLCEGGVFDAVTGGGHMGLVQLVRKMSTYDDSICLPDEIGKLAPTFYYRDDGLRLWEAIERFISDVIVHFYYSDSDVVQEDELQSWIC

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT83.4
NLMSIM90.0
AACOMP92.3
Seqdif (SeqID)45.2 (XP_048472315.1)
Structdif (F-Target)5.9 (3v92 B)

ProtNLM

NameScore
Arachidonate 5-lipoxygenase0.568
Arachidonate 5-lipoxygenase-like0.070
Arachidonate 12-lipoxygenase, 12R-type0.036
ALOX120.034
ALOX50.029
LOX5 lipoxygenase0.024
Designed by MP, using an AMD MI250 GPU