MWFS2

Prompt

1.14.18.7

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With another compound as one donor, and incorporation of one atom of oxygen. dihydroceramide fatty acyl 2-hydroxylase.

AI Generated Sequence

265 AAs
MLSLLENFWAWHRLMADDYVAATGWSLLLHEVVYFLFGLPYIILDRLPFFRKYKIQPSKPITPEQWRQCFKTVLLFHFLVVLPLQLASYPFMKFMGMRYSLPLPSWRTVMLQILAFLVMEDFTYYWVHRAMHTKWLYKHIHSVHHEYATPIGLAAEYAHPLEGLILGFTGFIGPLLMAGMHLLTMLLWAVRLLETIAVHCGYDFPWSLHHLIPFFGGADYHDVHHQLYGTGKYNFGQSTFTWWDYLGTDYPKAKALRKELAKKKA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT86.4
NLMSIM85.0
AACOMP88.8
Seqdif (SeqID)45.2 (XP_011624140.1)
Structdif (F-Target)56.2 (6za7 B)

ProtNLM

NameScore
Fatty acid hydroxylase domain-containing protein0.722
C-4 methylsterol oxidase0.076
1.14.18.90.020
Fatty acid hydroxylase superfamily-domain-containing protein0.014
C-4 methyl sterol oxidase0.011
C-4 sterol methyl oxidase0.009
Designed by MP, using an AMD MI250 GPU