MX2PU

Prompt

2.7.11.10

Transferases. Transferring phosphorus-containing groups. Protein-serine/threonine kinases. IkappaB kinase.

AI Generated Sequence

726 AAs
MSRPLQLKQQTCGAWEMKERLGTGGFGNVYRWQHQETGEKIAIKQCRLELSAKNKERWCHEIQIMKKLNHPNVVKACDVPEEMAQNVPLLAMEYCSGGDLRKLLNKPENCCGLKEGAILTLLSDIGSALQYLHENRIIHRDLKPENIVLQDVGGKLIHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELLENQKYTVTVDYWSFGTLAFECIAGFRPFLPNLQPFTWHEKVKQKGPKDIFVYEELSGEVRFSTHLPQPNNLCSLIAEPMEKWLQLMLNWDPRQRGGTVDYGPKPNCFKLLDHILNLKLVHILNMVSAKIHSYPVTPDESLHSLQARIERDTGIPETNQELLLEAGIALDPRKPATQCVIDGVKLDEGVRWDSYMVYLFDKSKTYEGPFAARSLPPDCVNYIVQDSKQNLPIFQLRKVWGEAVHYITGLKEDYSRLFQGQRAAMLNLLRYNANLTKMKNSMVSFSQQLKAKLDFFKTSIQIDLERYSDQMTYGIASEKMLKAWKEMEQLAEKEGLAVAMGALHTEIVELQKSPYGRKQGGVLEDLEQRAIDLYKQLREKPRDHTYSDSTEMVKIIVQTVQGSDKVLRDLYGHLSKTLGCKQKIIELLPKVEVALNNIKEAENMLVQMQGKRQKELWHLLKIACTSKVRSVGGSSDSMNARTLSQPAPLLLHSAGKENEVVQEANLCLSELSNILQDQTKDQNQTMLTDMNWTLLGNE

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT82.3
NLMSIM90.0
AACOMP92.6
Seqdif (SeqID)28.0 (XP_017688170.1)
Structdif (F-Target)5.5 (4kik A)

ProtNLM

NameScore
2.7.11.100.379
I-kappa-B kinase0.327
Nuclear factor NF-kappa-B inhibitor kinase alpha0.133
Inhibitor of nuclear factor kappa-B kinase subunit alpha0.094
IkBKA0.012
IKKA kinase0.005
Designed by MP, using an AMD MI250 GPU