MWVVD

Prompt

1.14.12.12

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor. naphthalene 1,2-dioxygenase.

AI Generated Sequence

282 AAs
MKKIVVVGGGFAGVELAGELAKKLGRKDYDITLVDRNNYHFQTPLLHQVATGTIEPGSIDIPFRGHFQRHNHFQFRLGEVTDIDREAKKIQLAGVEDYVAYDYLVIAVGSQTNNFGTPGVKEHCIGLKSVEDALNIRHHVLANFEKAYRLTTDPERAKLLNFAIVGGGATGVELAGELADIVKDLIPDYFPNIDKNLMNITLIEAGDRILAAMPEKISAYAHKHLTKLGVEVLTNAMVTSYEGDGYVKTDGKEIATDMTVWATGVKASPVMKDLGIETDNRG

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT95.0
NLMSIM65.0
AACOMP92.7
Seqdif (SeqID)50.7 (WP_072925364.1)
Structdif (F-Target)7.8 (5kmq C)

ProtNLM

NameScore
NAD(P)/FAD-dependent oxidoreductase0.328
FAD-dependent oxidoreductase0.272
NADH dehydrogenase0.180
Pyridine nucleotide-disulfide oxidoreductase0.055
Pyr_redox_2 domain-containing protein0.052
1.6.99.30.033
Designed by MP, using an AMD MI250 GPU