MTCMT

Prompt

6.3.3.1

Ligases. Forming carbon-nitrogen bonds. Cyclo-ligases. phosphoribosylformylglycinamidine cyclo-ligase.

AI Generated Sequence

351 AAs
MSDKKNGLTYKDAGVDIDAGNALVERIKPLVKATHRPGTDAEIGGFGGLFDLKATGYKDPVLVASTDGVGTKLKIAFDAGKHDTVGIDLVAMCVNDLVCQGAEPLFFLDYFATGKLDVDTGAAIVKGIAEGCEQAGCALIGGETAEMPGMYDGGDYDLAGFAVGAVERGKILDGKDIKEGDVLIGLASSGVHSNGFSLVRKIVEVSGAKLDAAPFDDGKTLGEALMEPTRIYVKPVLKLIKETGVKGIAHITGGGFTENIPRVLPEGLHAVIDLKSWTVPPVFAWLQETGNVAELEMYRTFNCGVGMVVAVAPEKADAVTAELNAAGETAWTAGTVVARGDEGCVFKGDLH

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT85.5
NLMSIM70.0
AACOMP89.5
Seqdif (SeqID)27.5 (WP_188130519.1)
Structdif (F-Target)7.7 (2v9y A)

ProtNLM

NameScore
AIRS0.291
AIR synthase0.242
Phosphoribosylformylglycinamidine cyclo-ligase0.197
6.3.3.10.153
Phosphoribosyl-aminoimidazole synthetase0.113
AIR synthetase0.000
Designed by MP, using an AMD MI250 GPU