MT6PM

Prompt

1.4.1.24

Oxidoreductases. Acting on the CH-NH2 group of donors. With NAD(+) or NADP(+) as acceptor. 3-dehydroquinate synthase II.

AI Generated Sequence

289 AAs
MKKSFWIKADDGGGWEEQKERITTGLESGVDCVLVNPGDVEKVRELGNITIAAFGDADIIVGKKGTGEVDGETTGKGTIPLPAGSFDISAATLTRDKGVTVAGYVRIKDKDYERFAAEMGKVCDYVIVTGTDWQVIPLENLIADRLQHETKLIAGVKTAEEARLAFQTLEHGADGVLLDSDQPDQIKDTAAVRESEDERESLELVYATVTKVEPVGMGDRVCIDTCNLMQMGEGMLIGSQSSGLFLVHAESAESPYVAARPFRVNAGAVHAYIRVGGGKTRYLSELKAG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT70.7
NLMSIM85.0
AACOMP92.3
Seqdif (SeqID)27.5 (WP_322222725.1)
Structdif (F-Target)24.4 (1yad B)

ProtNLM

NameScore
3-dehydroquinate synthase II0.377
3-dehydroquinate synthase0.232
1.4.1.240.144
DHQ synthase0.107
4.2.3.40.093
4.1.99.-0.003
Designed by MP, using an AMD MI250 GPU