MRQE8

Prompt

4.1.3.4

Lyases. Carbon-carbon lyases. Oxo-acid-lyases. hydroxymethylglutaryl-CoA lyase.

AI Generated Sequence

351 AAs
MTLPKNVKIVEVGPRDGLQNEKKTVPVGAKIELINLLSATGLTVIEATSFVSPKWVPQMADHAEVMAQIRRVPGVTYSALTPNIKGFEQALAAGCDEVAVFAAASETFSQKNINCSIAESLERFAPVTAAAKAHGVRVRGYVSCVLGCPYEGDIPPAQVAEVAKRLYDMGCYEISLGDTIGTGTAGTTKRILDVVAAEIPRDKLAVHFHDTYGQALANIYASLELGIRVFDSSVAGLGGCPYAKGASGNVATEDVVYMLNGLGIETGIDLDKLIDAGNFICQALGRNTPSRVALANLAKKDAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

acetyl-CoA

CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O

Validation Metrics

PLDDT95.0
NLMSIM90.0
AACOMP83.4
Seqdif (SeqID)25.2 (WP_071487114.1)
Structdif (F-Target)2.1 (1ydo A)

ProtNLM

NameScore
4.1.3.40.619
Hydroxymethylglutaryl-CoA lyase, mitochondrial0.260
Hydroxymethylglutaryl-CoA lyase0.054
3-hydroxy-3-methylglutarate-CoA lyase0.054
HMG-CoA lyase0.002
Pyruvate carboxyltransferase domain-containing protein0.001
Designed by MP, using an AMD MI250 GPU