MKH49

Prompt

2.5.1.60

Transferases. Transferring alkyl or aryl groups, other than methyl groups. Transferring alkyl or aryl groups, other than methyl groups. protein geranylgeranyltransferase type II.

AI Generated Sequence

579 AAs

MHGRIKVKTSEEQAAKAREEREQKLKLYTAATQAVFQKRQSGELDEEVLELTSQILSANPDFATLWNYRREVLLREETQKSPEELAALYKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWARELGLCDRFLSLDERNFHCWDYRRMVARTAGVPAEEELAFTDTLITRNFSNYSAWHYRSTLLPLLHPQPDPGQGPGEPGQPERQLLPEDVLLKEFELVQNAFFTDPNDQSAWFYHRWLLGRADPQQLRCLHVVSRDEACLAVSFSRLPVVERETEILLMVDGEPLAVIRWTPVDGRNRSHVWLCDLPDASLNDGSQHTRFVWTAEGHRQECVLLGKRQEGWCRDSATDEQLFRCELSVEKASVLQSELESCKELQELEPQNKWCLLTIILMLRALDPLGYEKTLQHFEEEQAQYFTKLMKVADPMRSAYLDLRSKKFLEENSVIKMEYAEVRVLHLSHKDLTVLCHLEDQLLVTHLDLSHNRLHALPPAMLARLCEVLQLADNNAIESLDGVTHLPKLEEILRLNNRQLQTPALQPLASCRKLVLDLNGNPLCQASGEVQKLESTLEPVSTIM

Ligand/Cofactor

PLP

CC1=NC=C(C(=C1O)C=O)COP(=O)(O)O

Validation Metrics

PLDDT	75.9
NLMSIM	95.0
AACOMP	90.4
Seqdif (SeqID)	25.2 (XP_023083091.1)
Structdif (F-Target)	15.6 (1ltx A)

ProtNLM

Name	Score
Geranylgeranyl transferase type II subunit alpha	0.386
Geranylgeranyl transferase type-2 subunit alpha	0.321
2.5.1.60	0.245
Rab geranyl-geranyltransferase subunit alpha	0.017
Rab geranylgeranyltransferase subunit alpha	0.005
Rab GGTase alpha	0.004