MJAL6

Prompt

1.5.1.2

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. pyrroline-5-carboxylate reductase.

AI Generated Sequence

270 AAs
MTAAAIIGAGNMGAALISGLLAAGLPAGDITVADPNPARAAALAARYGVRAAADNAAAVAGADLVVLAVKPQVMAEVCAELAPALAPGAPLVVSIAAGITIAAFEAWFGAGAPVVRAMPNTPALVGAGMTGLAANAHVTAEDRARAEALFAAVGEVVWVPEEAQIDAVTALSGSGPAYFFHLIEAMTEAGVALGLPRATAQRLAAQTVLGAAAMLAESDEDPAALRANVTSPKGTTEAALRVFEAHGLRPLIERAIAAARDRSRELGQAL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT97.5
NLMSIM85.0
AACOMP80.2
Seqdif (SeqID)38.7 (WP_136490453.1)
Structdif (F-Target)5.0 (2ag8 A)

ProtNLM

NameScore
PCA reductase0.259
1.5.1.20.219
P5CR0.180
Pyrroline-5-carboxylate reductase0.174
P5C reductase0.165
Methylenetetrahydrofolate dehydrogenase0.000
Designed by MP, using an AMD MI250 GPU