M98LA

Prompt

2.1.1.67

Transferases. Transferring one-carbon groups. Methyltransferases. thiopurine S-methyltransferase.

AI Generated Sequence

218 AAs

MDPEFWQEKWAANQIGFHQPEVNPYLVKHWPALGLPAGARVFVPLCGKSLDMCWLAAQGHRVVGCELSERAVREFFQEHGLQPETVQTGARFVYRADSISLWCGDLFALPAASIADVCAVYDRAALIAWPPEMRARYAQHLARLLPPGCRGLLVTLDYPQPALHGPPFAVSDAEVRAYLGGFDIEILEAQDDVLAENPRFVKKGVPSLAERVYRLVKR

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT	95.8
NLMSIM	90.0
AACOMP	91.2
Seqdif (SeqID)	38.7 (WP_213660131.1)
Structdif (F-Target)	7.2 (2h11 B)

ProtNLM

Name	Score
Thiopurine S-methyltransferase	0.417
Thiopurine methyltransferase	0.372
2.1.1.67	0.203
Methyltransferase domain-containing protein	0.000
Thiopurine s-methyltransferase	0.000
SAM-dependent methyltransferase	0.000