MIKTM

Prompt

2.1.1.173

Transferases. Transferring one-carbon groups. Methyltransferases. 23S rRNA (guanine(2445)-N(2))-methyltransferase.

AI Generated Sequence

500 AAs
MRERFFTACPKGLEGLLAEELAGLGLEEVRETAAGVRFRGDLALAYRLCLWSRLASRVLLLLREFPVEDAEALYAGVEAVPWQEHLAPGDTLAVDFHGTNDAIRNTQFGALRVKDAIVDRLRAETGLRPSVDKDNPDLRVHARLDRGEAVLSLDLSGPSLHQRGYRRLAGQAPLKENLAAAVLVRSGWPRAGGEGGPLADPMCGSGTFLIEAALMAADIAPGLRRERFGFAAWRGHDPALWRRLREEAEARAAAGAARLPLRIRGYDADPRVLEPARRNAERAGVADWIEFQVGDVAALEPPPDPARGLVVCNPPYGERLGEEPALLALYQRLGRVLREACGGWRAAVFTGAPELLGRLGMRAHRQYRLWNGALECVLLTYRVAPEQTFRPEGAEMFANRLQKNLRQLGKWARREGIECYRLYDADMPEYALAVDLYGDWVHVQEYAAPASVPPEDARRRLADVLAAAPAVAGVPAERVVLKTRERQSGTQQYERLAAEG

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT89.2
NLMSIM85.0
AACOMP87.4
Seqdif (SeqID)34.4 (WP_312713346.1)
Structdif (F-Target)7.7 (3ldg A)

ProtNLM

NameScore
23S rRNA m2G2445 methyltransferase0.248
2.1.1.2640.191
Ribosomal RNA large subunit methyltransferase K/L0.157
23S rRNA m7G2069 methyltransferase0.140
RRNA (guanine-N(7)-)-methyltransferase RlmK0.125
RRNA (guanine-N(2)-)-methyltransferase RlmL0.085
Designed by MP, using an AMD MI250 GPU