MHQHN

Prompt

6.3.2.17

Ligases. Forming carbon-nitrogen bonds. Acid--amino-acid ligases.(peptide synthases). tetrahydrofolate synthase.

AI Generated Sequence

485 AAs

MTDLDDLERLLELERPLHPEQIDPSLERMRRLADRLGHPERKFPPVIHVAGTNGKGSTVAMLESILAAQGLRVGLYTSPHLVHFNERIALNGEPVPEAEFLAVWEQVEPLLEGEGGELSTFFEITTVMAFRLFAEEPVDLAIVEVGLGGRWDSTNVIDTDVAVITNIGLDHQDYLGDTLESIAFEKAGIIRKGAPVVVGPQDPEAAAVIERAREVGAEPLLVEGRDFWAVMDQKGWRYSQGGRYGDLQLPLLRGDHQALNAAVALAAFEFLREQGLPLSEAEIRAGLANARLPGRFQRLSGEPVVLLDGAHNPAGARALAETLAELGFDGRYRLVFGAMADKDVAGMLAPLEPLADWLVTALPSEPRALPAEELAAAGRRLGFEGVEAYASVAAALEAARRAAEGDDRIVVTGSFLTAEVVRAAIEGPLPEGRGEGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT	86.8
NLMSIM	70.0
AACOMP	85.7
Seqdif (SeqID)	49.6 (MED5618330.1)
Structdif (F-Target)	6.0 (1w78 A)

ProtNLM

Name	Score
Bifunctional folylpolyglutamate synthase/dihydrofolate synthase	0.444
6.3.2.17	0.110
Dihydrofolate synthase/folylpolyglutamate synthase	0.107
Folylpolyglutamate synthase	0.075
Dihydrofolate synthase / folylpolyglutamate synthase	0.057
6.3.2.12	0.043