M2E7O

Prompt

6.3.2.12

Ligases. Forming carbon-nitrogen bonds. Acid--amino-acid ligases.(peptide synthases). dihydrofolate synthase.

AI Generated Sequence

485 AAs
MTDLDDLERLLELERPLHPEQIDPSLERMRRLADRLGHPERKFPPVIHVAGTNGKGSTVAMLESILAAQGLRVGLYTSPHLVHFNERIALNGEPVPEAEFLAVWEQVEPLLEGEGGELSTFFEITTVMAFRLFAEEPVDLAIVEVGLGGRWDSTNVIDTDVAVITNIGLDHQDYLGDTLESIAFEKAGIIRKGAPVVVGPQDPEAAAVIERAREVGAEPLLVEGRDFWAVMDQKGWRYSQGGRYGDLQLPLLRGDHQALNAAVALAAFEFLREQGLPLSEAEIRAGLANARLPGRFQRLSGEPVVLLDGAHNPAGARALAETLAELGFDGRYRLVFGAMADKDVAGMLAPLEPLADWLVTALPSEPRALPAEELAAAGRRLGFEGVEAYASVAAALEAARRAAEGDDRIVVTGSFLTAEVVRAAIEGPLPEGRGEGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT86.8
NLMSIM90.0
AACOMP85.7
Seqdif (SeqID)49.6 (MED5618330.1)
Structdif (F-Target)6.0 (1w78 A)

ProtNLM

NameScore
Bifunctional folylpolyglutamate synthase/dihydrofolate synthase0.444
6.3.2.170.110
Dihydrofolate synthase/folylpolyglutamate synthase0.107
Folylpolyglutamate synthase0.075
Dihydrofolate synthase / folylpolyglutamate synthase0.057
6.3.2.120.043
Designed by MP, using an AMD MI250 GPU