MF8UM

Prompt

2.1.1.45

Transferases. Transferring one-carbon groups. Methyltransferases. thymidylate synthase.

AI Generated Sequence

264 AAs
MKQYLDLMRHVLDHGTQKGDRTGTGTLSVFGHQMRFDLSEGFPLVTTKKLHLKSIIHELLWFLKGDTNIKYLQENGVSIWDEWADENGDLGPVYGHQWRSWPTPDGGTIDQISWLIEQIKTNPDSRRIIVSAWNVGELPKMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVCDLEPGEFIHTFGDAHLYLNHLEQARLQLSREPRPLPKMKINPEVKDIFAFKFEDFELEGYDPHPHIKAPVAV

Ligand/Cofactor

S-adenosylmethionine

C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

Validation Metrics

PLDDT95.7
NLMSIM85.0
AACOMP93.4
Seqdif (SeqID)15.2 (BDD10636.1)
Structdif (F-Target)0.9 (3b5b B)

ProtNLM

NameScore
TSase0.313
TS0.268
Thymidylate synthase0.262
2.1.1.450.154
FDTS0.000
FAD synthase0.000
Designed by MP, using an AMD MI250 GPU