MEN88

Prompt

2.7.11.31

Transferases. Transferring phosphorus-containing groups. Protein-serine/threonine kinases. [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.

AI Generated Sequence

427 AAs
MTTTSRIPGFYKLSVEERLDWLRSLAGLSDEQVRQLASPGELPVQQADEMIENVIGTFYLPLGVATNFLINGRDALIPMATEEPSVVAAASFMAKVAREGGGFTATSSTPVMIGQVQLVDVPDPHAAREALLARADEIIRLANSHDPTLVKFGGGCRDIEVRVLPTSPGPMVVLHLLVDVRDAMGANAVNTMAEGLAPLLEKLTGGGVLLRILSNLATDRLARAWARYPAEYLSDGGNFGGEVVRGILNAYTFAAVDPYRAATHNKGIMNGIAPVALATGNDWRAVEAGAHAYAARSGRYDSLTRWERDADGRLVGELELPMPVGLVGGATKLHPLAKLSLKILGVSSARELGQMVASVGLAQNLGALRALATTGIQRGHMALHARNIAVAAGATGEVIDAVAKRFAAEDVRVDRARELLAESRREG

Ligand/Cofactor

NADPH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O

Validation Metrics

PLDDT91.0
NLMSIM75.0
AACOMP91.9
Seqdif (SeqID)33.1 (WP_056184628.1)
Structdif (F-Target)6.0 (1qax A)

ProtNLM

NameScore
HMG-CoA reductase0.403
3-hydroxy-3-methylglutaryl coenzyme A reductase0.272
1.1.1.880.271
Hydroxymethylglutaryl-CoA reductase, degradative0.041
1.1.1.340.004
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase0.000
Designed by MP, using an AMD MI250 GPU