MAE0W

Prompt

1.5.1.3

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. dihydrofolate reductase.

AI Generated Sequence

161 AAs
MKISLIVAMAENRVIGKDNQLPWHLSADLKHFKRLTMGHPIIMGRKTYESIGRPLPGRTNIVISRQADFSAEGCTVVHSVEEALAAAGDVEEVMIIGGGEIYKQALPLADRLYLTKVHATFEGDTYFPEFDWAEWELVSREDHPADEKNHYAYTFLTLERK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT94.5
NLMSIM70.0
AACOMP94.5
Seqdif (SeqID)31.7 (WP_266052214.1)
Structdif (F-Target)1.6 (5w3q A)

ProtNLM

NameScore
1.5.1.30.561
Dihydrofolate reductase0.436
Methylenetetrahydrofolate reductase0.000
Bifunctional dihydrofolate reductase-thymidylate synthase0.000
DHFR domain-containing protein0.000
Diacylglycerol kinase0.000
Designed by MP, using an AMD MI250 GPU