M8UDS

Prompt

1.3.1.48

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. 15-oxoprostaglandin 13-reductase.

AI Generated Sequence

329 AAs

MIKKVVWNLKDRFEGYPKADNFKLETVELPEINEGEVLLEKLYLSVDPYMRAFMRKEMPVGETMIGGQVARVVESKNPEYKVGDYVAGNMGWQTYSVIDGDNLEKVIPDQVDLPSLALGAIGMPGMTAYAGLLEIGCVKEGDTVLVNAAAGAVGSVVGQIAKIKGCKKVIGIAGSDEKVEWLKELGFDEAVNYKTEENLAEALKEASPEGYDCYFDNVGGEFSNAVIAQMKNFGRIAICGQISQYNDTVPPPGPPPEQIYRELRMEGFIVQRHGDWREGMLKQLMNWVNEGKIKYKEHITEGLENMPEAFIGMMKGENIGKKIVKVADE

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	89.2
NLMSIM	70.0
AACOMP	89.5
Seqdif (SeqID)	37.4 (XP_053887594.1)
Structdif (F-Target)	3.4 (1v3t B)

ProtNLM

Name	Score
NAD(P)H-dependent alkenal/one oxidoreductase	0.195
1.3.1.74	0.172
Dithiolethione-inducible gene 1 protein	0.161
Prostaglandin reductase 1	0.148
15-oxoprostaglandin 13-reductase	0.124
Leukotriene B4 12-hydroxydehydrogenase	0.117