M6ULY

Prompt

1.14.13.33

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 4-hydroxybenzoate 3-monooxygenase [NAD(P)H].

AI Generated Sequence

657 AAs

MKTQVAIIGAGPAGLLLGQLLHNAGIDTVILERQSGDYVLGRIRAGVLEQGTVDLLREAGVARRMHAEGLVHDGIELAFDGKRMRIDLHGLTGGKHVTVYGQTELTRDLMDARAATGGVTIYEAENVQIHDFKGDKPYVTYVKDGQTHRIDCDFIAGCDGFHGVSRKSIPAGALKVYEKVYPFGWLGILADTPPVSHELIYANHERGFALCSMRSLTRSRYYLQVSLEDKVEAWSDERFWDELKARLPEHLADSLVTGPSIEKSIAPLRSFVVEPMQYGRLFLVGDAAHIVPPTGAKGLNLAASDVSYLYRILKVYYEEGRTGLLDRYSQMCLARVWKAERFSWWMTSMLHMFPDQAAFDQKIQAAELDYLVSSEAGQSTIAENYVGLPYEPAGLRDEAIHAGDVRHVGRAIARLGMDFIAGCDGFHGVSRQSIPAGAIKEYERVYPFGWLGILADTPPVSNELIYANHERGFALCSMRSPTRTRYYIQVSLNDKVEAWSDARFWTELKARLPADLHASLVTGPSFEKSIAPLRSFVVEPMQYGRLFLVGDAAHIVPPTGAKGLNLAASDVSYLYSLLKVAYEEGRTGLIDRYSQMCLARVWKAERFSWFMTQLLHRFPDQGDFGQRIQAAELDYLVHSEAGQTAIAENYVGLRMEA

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT	87.2
NLMSIM	90.0
AACOMP	95.7
Seqdif (SeqID)	22.2 (WP_274125608.1)
Structdif (F-Target)	0.9 (1dob 2)

ProtNLM

Name	Score
1.14.13.2	0.573
4-hydroxybenzoate 3-monooxygenase	0.299
P-hydroxybenzoate hydroxylase	0.061
4-hydroxybenzoate hydroxylase	0.032
P-hydroxybenzoate 3-monooxygenase	0.009
FAD_binding_3 domain-containing protein	0.002