M5OK7

Prompt

1.1.1.43

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. phosphogluconate 2-dehydrogenase.

AI Generated Sequence

500 AAs

MAEKKIGLIGLAVMGQNLILNMNDHGFTVAVYNRTVDKVDEFLANAPEGKNIVGAYSLEEMVAKLKRPRKVIMLVKAGAPVDAFINQLVPLLEKGDIIIDGGNSLFQDTNRRTKYLREKGILYVGTGVSGGEEGARFGPSLMPGGSKEAWPHIKPIFQSIAAKTDTGEPCCDWVGDRGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMSADEMHAVFTEWNKGELDSYLIEITADILFKKDEDGKYLVDKILDTAGQKGTGKWTSINALDLGVPLTLIGEAVFARCVSALKDERVQASKLLQGPKTKFEGDKAAFIEDLRQALYASKIISYAQGFMLMREAAKEYGWNLNYGGIALMWRGGCIIRSAFLGKIKDAYDRNPDLENLLFDPYFKKAIENCQDSWRKVVSTALLNGIPVPAFSTALAFYDGYRSEVLPANLLQAQRDYFGAHTYERLDKPRGEFFHTNWTGRGGKVTSSTYNADTKKKKKKKKKKKKKKK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	93.3
NLMSIM	60.0
AACOMP	92.7
Seqdif (SeqID)	22.2 (HHV96755.1)
Structdif (F-Target)	1.6 (5uq9 E)

ProtNLM

Name	Score
1.1.1.44	0.610
6-phosphogluconate dehydrogenase, decarboxylating	0.381
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)	0.003
6PGD domain-containing protein	0.001
NADP-dependent phosphogluconate dehydrogenase	0.001
Glucose-6-phosphate 1-dehydrogenase	0.000