M0YPZ

Prompt

1.13.11.26

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. peptide-tryptophan 2,3-dioxygenase.

AI Generated Sequence

283 AAs
MSDNPRTVAMEKGIHTDFKESMTYGDYLRLDQILSAQLPLSEPHHDEMLFIIQHQTSELWMKLVLHELRAARIAIQKDGELPAFKMLARSKSIFQQLTQSWSVLETLTPSEYIEFRDFLGQSGFFQSQYQRLIEFALGNKNPAMLKVFKSDPELHKALTEALHAPSLYDEALRYLVRHGFHIDEKAVLRRWTQPYAENPSVEAAWVRIYRNPDKYWDLYQLCEKLIDVENQLQQWRFNHIMTVQRIIGFKMGTGGSSGVKYLKRALDTRFFPELWDVRTSLGK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.2
NLMSIM70.0
AACOMP93.3
Seqdif (SeqID)35.2 (HDR7794725.1)
Structdif (F-Target)2.3 (2nox I)

ProtNLM

NameScore
TRPO0.168
Tryptamin 2,3-dioxygenase0.159
TDO0.123
TO0.110
Tryptophanase0.108
1.13.11.110.097
Designed by MP, using an AMD MI250 GPU