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2 docs tagged with "inversefolding"

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Protein Design

Protein design involves creating proteins with specific functions by manipulating their amino acid sequences. This process allows scientists to develop a range of applications, such as anti-cancer drugs (e.g., antibodies), gene editing tools (e.g., Cas9), laundry detergents (e.g., amylases), and digestible milk (e.g., lactases). While protein engineering typically refers to small modifications of natural proteins, protein design encompasses more extensive alterations. De novo protein design specifically refers to creating sequences from scratch.

ProteinMPNN

ProteinMPNN is a GNN-based AI method for designing a protein sequence given a protein structure. This is called structure-based design or inversefolding. LigandMPNN is coming soon.