M8WHU

Prompt

3.5.4.39

Hydrolases. Acting on carbon-nitrogen bonds, other than peptide bonds. In cyclic amidines. GTP cyclohydrolase IV.

AI Generated Sequence

376 AAs

MTHLPDVQASRPDVQAGPAYRGIGLTQVGVTGVRPVVIGRDGGPRDVLLTATFDTSVDLPAGRKGINMSRFNEAIAELLEQAVGPAYSVEEVCADAVRLLLGHHEFARDAEVRMRSEFMVRREALPTLGLSQEAYPVIAEAVAGRGVRRKVIEGVVVATMTPCSAELSQRAAQGIVRDAAARALGVDAETVARFLEGVVPLATHHQRSVATLTVEAGGDVDLGLEDLIAIVRQSMSATVEALVKRADEAVVAEAHALNAKFVEDCARAMARRVLDAFPHLRDAFVVVRHQSNESIHHDVNALTEREATLGTLRDPALAATHLHGPGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

GTP

C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N

Validation Metrics

PLDDT	78.5
NLMSIM	60.0
AACOMP	81.2
Seqdif (SeqID)	56.3 (WP_048124164.1)
Structdif (F-Target)	10.5 (3d2o A)

ProtNLM

Name	Score
GTP cyclohydrolase I FolE2	0.267
GTP cyclohydrolase FolE2	0.156
GTP cyclohydrolase MptA	0.152
GTP cyclohydrolase IV	0.140
3.5.4.39	0.128
GTP cyclohydrolase	0.032