MDWFW

Prompt

1.14.19.59

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. tryptophan 6-halogenase.

AI Generated Sequence

499 AAs
MSEIKRVVIVGGGTAGWMTAAYLARLLGEDVEVTLVESPEIGTVGVGEATVPPLRRFNQLLGIDENEWMRHAGATFKLGIEFVNWGRLGDSYIHNFGTLGHDLPGCRFFHAWLKAQQNGLAAPLSDYSCSQLAAENGKFATPLSPNSPLDGLNYAYHFDAGLYARYLRSYAESRGVTRVEGKITAVEQDPENGYINSLVLENGQIEGDLFVDCTGFRGLLIGEALKTGHYEDWSHYLPCDAAVAVQCETPNGEIPYTRAIAHEAGWQWRIGLQHRTGNGHVYCSQYMSDEDAKALLLDHLDGKPLAEPRTLKFRTGRRQKHWNKNCVAVGLASGFLEPLESTSIHLIQSGIHRLVSLFPDRGFDPALAEEYNRQTESEYERIRDFLILHYKATERDDTPFWRHCRDMAVPESLTEKIDLFKAEGRFVREGSELFRTASWLQVMLGQGLIPRDYHPLADKLPDRDLADFLRGIRNHVRAASEQMPSHTDFVQQYCATSVA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT91.0
NLMSIM85.0
AACOMP95.5
Seqdif (SeqID)39.8 (WP_198099377.1)
Structdif (F-Target)2.3 (6y1w B)

ProtNLM

NameScore
Tryptophan halogenase0.841
Tryptophan 7-halogenase0.102
1.14.19.90.015
Flavin-dependent tryptophan halogenase RebH0.007
Tryptophan halogenase,0.006
Tryptophan halogenase family protein0.003
Designed by MP, using an AMD MI250 GPU