MWKBE

Prompt

1.1.1.99

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. (S)-2-hydroxy-fatty-acid dehydrogenase.

AI Generated Sequence

479 AAs

MYDFVIIGAGIIGMSTAMQLIDVYPDARIALLEKESGPACHQTGHENSVIHAGVYYTPGSLKAQFCLAGNRATKTFCDQNGIRYDNCGKMLVATSELEMERMRALWEATAANGIEREWLSAERLRERTPNITGLGGIFVPSSGIVSRDAVAAAMAKIFQSRGGEIIYNAEVSALGEHKNGVVIRTRQGGEIEASTLIACSGLMAADRLVKLGIEPGFIICPFRGEYFRLAPEHNQIVVHLIYPIPPAATPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSLSDTLEILPSPGIRRVLQNHLRSGLGEKMNRSLKSGYLRLVQKYCPSRSLQDLQPWPAGVRAQAVSPDGKLIDDFLVVTTRSIIHTANAPSLPATSAIPLIGAHISKVQTLLASQSINPGRTLAARSVDALHAAFNRQGEIIAAGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	80.2
NLMSIM	70.0
AACOMP	88.3
Seqdif (SeqID)	10.8 (HAN4259001.1)
Structdif (F-Target)	5.2 (8w7f C)

ProtNLM

Name	Score
L2HG dehydrogenase	0.313
L2HG:quinone oxidoreductase	0.256
1.1.5.13	0.214
L-2-hydroxyglutarate dehydrogenase	0.167
1.1.3.-	0.020
L2HG oxidase	0.003