M9HNU

Prompt

1.14.13.10

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With NADH or NADPH as one donor, and incorporation of one atom of oxygen. 2,6-dihydroxypyridine 3-monooxygenase.

AI Generated Sequence

292 AAs
MAGLLARRLKGLDYDVTVLSRNPYTFTQPFLHEVATGSLESRAIAEVPLRAHARKHNVFELQGEVTAIDRATKRITLSEGDRYVSYDYLVIAAGCRTNYFGIPGVAEHCFHLKDVEDAQRIRRRIMDNFELAESITDEERRRLLNFSVIVGGGPTGVELAGELHDLVNTLADKYPNIDPELLRISLIQAGRHILAMFPEKISAYAEKEFSKRGVDVRLTGKRVTEVDEGVTITKDGTEIPATMLVWSAGVRAPFLKEMEQLGLDRRGRLLVDETHLRSGDDNYVGFGDGIAV

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT91.2
NLMSIM75.0
AACOMP93.9
Seqdif (SeqID)56.0 (KAJ0264934.1)
Structdif (F-Target)9.3 (5kmq C)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.571
FAD-dependent oxidoreductase0.095
NAD(P)/FAD-dependent oxidoreductase0.054
FAD/NAD(P)-binding domain-containing protein0.045
FAD-dependent pyridine nucleotide-disulfide oxidoreductase0.044
NADH dehydrogenase0.038
Designed by MP, using an AMD MI250 GPU