MZO5J

Prompt

1.2.1.27

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. methylmalonate-semialdehyde dehydrogenase (CoA acylating).

AI Generated Sequence

499 AAs
MTEIGHFIDGKFVEGKSSRFADVFNPATGEVQGKVALASKEEVDAAVAAAKAAQPAWADTNPQKRARVMFKFRELLNKNMDELAELISREHGKTLADAKGDVQRGLEVVEFACGIPHLLKGEFTENAGPGIDVYSMRQPLGVVAGITPFNFPAMIPLWMFGPAIACGNTFILKPSERDPSVPLRLAELFLEAGLPKGVFNVVNGDKEAVDAILTHPDIKAVSFVGSTPIAEYVYETGTANGKRVQCFGGAKNHMIVMPDADLDQAANALMGAGFGSAGERCMAISVAVPVGEITADRLVPMLKERIEKLKVGPGTDPKGVDMGPLVTKQARDKVLGYIDSGVEEGAKLVVDGRDFKVQGYENGFWVGPTLFDHVTPDMDIYKEEIFGPVLSVVRVKSYEEALKLVNDHEYGNGVAIFTRDGDAARDFQHRVEVGMVGINVPIPVPLAYHSFGGWKASGFGDLNAHGPDGVRFYTKTKTVTSRWPSGIKDGAEFNIPTMK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT92.3
NLMSIM80.0
AACOMP92.4
Seqdif (SeqID)22.4 (HWU63524.1)
Structdif (F-Target)1.3 (4zz7 G)

ProtNLM

NameScore
CoA-acylating methylmalonate-semialdehyde dehydrogenase0.267
Methylmalonate-semialdehyde dehydrogenase0.190
1.2.1.270.158
Methylmalonate-semialdehyde dehydrogenase (CoA acylating)0.156
Methylmalonate-semialdehyde dehydrogenase [acylating]0.051
Methylmalonate-semialdehyde dehydrogenase (Acylating)0.049
Designed by MP, using an AMD MI250 GPU