MZM9I

Prompt

1.2.4.4

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With a disulfide as acceptor. 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).

AI Generated Sequence

258 AAs

MTDRPGTLDDALLLEGMRHMMTLRAFDRRMMVAQRQGKLSFYVQCHGEEAISCAFRRALDRDDMRFPQYRQDAGLLIADGYPLADMMCQAFSNETDPAGGRQLPMHYSAKEHGFFSISGNLGTQFVQAVGWAMASAIKTDHRITACWIGEGSTAESDFHNAMVFASVYRAPVILNIVNNQWAISTFEQAGRHEDVSFAARGHGYGIPSLRVDGNPDFAVYAVKAWAERARARNLGPTLIEHVTYRAGAHSSDDPSAYR

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	88.0
NLMSIM	60.0
AACOMP	91.8
Seqdif (SeqID)	26.3 (WP_036359014.1)
Structdif (F-Target)	4.8 (1umb C)

ProtNLM

Name	Score
Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain	0.526
2-oxoisovalerate dehydrogenase subunit alpha	0.276
1.2.4.4	0.186
Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	0.001
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) subunit alpha	0.001
E1_dh domain-containing protein	0.001