MZKWJ

Prompt

1.5.1.53

Oxidoreductases. Acting on the CH-NH group of donors. With NAD(+) or NADP(+) as acceptor. methylenetetrahydrofolate reductase (NADPH).

AI Generated Sequence

500 AAs
MKITDLLKENKSVFSFEFFPPKTEGMEINLYRTIDEMREMDPNFIDVTYGAGGSTRERTIEICARIQKETGLTPVAHLTCINQSKEELNQDLLDLYNLGITNVLALRGDPPKMGEKWKTPHDGFKYASDLVKFIKQEYKNDHFCIGVACYPEHPESPNFELSDIKHLKEKVDAGAQFIITQLFFDVENYFDFMDRCRAAGITVPIIPGIMPITKYKQLSRMSSLCGVHIPESLLDALEKCKDDEAVREVGIEYTIKQCRDLIDAGVDGVHLYTMNRSAVTQEIMNKLGILKPEQVPHLLPRYSLSGGRRNEEVRKAIFEERRSRSYIATQEIWDEFPNGWRGDSSNPAFGELDGYGIFIRTNSKEGWELFGKPKSIQDILQQFYEVLKGKITCLPWNLQNLSNETTIIGEELDVLNKQGFLIIGQPNVDVGKSSDPVFGWGHPNGKIVYQKGYLEFISPEKLQDLIEIKKELNPNVEFVVNQKDGEFRVNPEGDLNAVTW

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT70.8
NLMSIM63.1
AACOMP91.9
Seqdif (SeqID)53.8 (KXN68030.1)
Structdif (F-Target)4.0 (7th5 B)

ProtNLM

NameScore
1.5.1.200.631
Methylenetetrahydrofolate reductase0.284
5,10-methylenetetrahydrofolate reductase0.080
Methylenetetrahydrofolate reductase (NAD(P)H)0.001
Dihydrofolate reductase0.000
Methenyltetrahydrofolate cyclohydrolase0.000
Designed by MP, using an AMD MI250 GPU