MZB59

Prompt

1.2.1.41

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. glutamate-5-semialdehyde dehydrogenase.

AI Generated Sequence

420 AAs

MTDLDTLMTDLGRRAREAARVLARASTAQKNRALLAMADAIEANADAILAANARDLEAGRANGLPEAMLDRLALTEKRIDGMVEGLRQVAALPDPVGEVLASWTRPNGLHIRRVRTPLGVIGVIYESRPNVTADAAALCLKSGNAVILRGGSEAFHSNAAIHACLREGLEAAGLPADAVQLVPTTDRAAVGEMITARGYVDVIVPRGGKSLVERVQREARVPVFAHLEGNCHVYVDASADLDKAVPIALNAKTQRTGVCGAAETLLVHRDVAERHLPPLLEALRDAGVELRGCERTRAILPDVVPATEEDWGTEYLDAILAVRVVDGLDAAIAHIRTHGSGHTDAIVTEDLAAARRFVAEVDSAIVMRNASTQFADGGEFGFGAEIGIATGKLHARGPVGVEQLTSFKYLVLGDGQVRPA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	96.5
NLMSIM	85.0
AACOMP	89.7
Seqdif (SeqID)	31.4 (WP_153347171.1)
Structdif (F-Target)	2.5 (1o20 A)

ProtNLM

Name	Score
GSA dehydrogenase	0.186
GPR	0.176
Glutamate-5-semialdehyde dehydrogenase	0.161
Gamma-glutamyl phosphate reductase	0.160
Glutamyl-gamma-semialdehyde dehydrogenase	0.159
1.2.1.41	0.154