MZ9PH

Prompt

1.13.11.23

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. 2,3-dihydroxyindole 2,3-dioxygenase.

AI Generated Sequence

372 AAs
MSEIPVIDLSSLSSGDPAARDAFAAEIARACREWGFFQVTGHGIDEALIDRVFAASREFFALPLEEKRRYDIPPSGGHRGYETPGGERLAAGKPADWKESFHIGYEVPAGDPYADPLLPGNEWPEAMPGFRETMAAYYAAMEALGVRLLRALAEALGLEEDFFDAWCDDGNSILRLIHYPPQCAPPPDGNARAGAHTDYGCITLLLQDQVGGLQVLHRDGEWIDAPPLPGALVVNVGDMLQRWTNDRYKSTVHRVVINRRGESRYSIAFFLNPRADALVEPLPGCVDAENPARYEPITAGEYLHGRLKATEGKRRPELRAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT92.4
NLMSIM75.0
AACOMP83.4
Seqdif (SeqID)46.2 (RPH46830.1)
Structdif (F-Target)7.4 (3oox B)

ProtNLM

NameScore
Fe2OG dioxygenase domain-containing protein0.319
2-oxoglutarate-dependent dioxygenase0.052
Oxidoreductase0.031
1.13.12.190.023
Isopenicillin N synthase0.021
2OG-Fe(II) oxygenase0.020
Designed by MP, using an AMD MI250 GPU