MZ2TI

Prompt

1.13.11.31

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 12-lipoxygenase.

AI Generated Sequence

662 AAs

MPSYTVTVATGSQWFAGTYDSISLTLVGERGSAEKQLLDRPFYDDFERGAVDYDVQCPEDLGELILVLKIEKHKWFPRDDWYCRYITVTRPADGSYVEFPCYRWIDGEEVELRPGRATRLQDSDQLLLQKHRRQELETRRQRYRWSQWLPGFPIAIDSCHLPLPLRDDMRFEEGAFDFTLYSNAEILNRMNFLGFMQSWSDWIDDFKKIFPWSKTMSEYVNEHWHSDEFFGYQFLNGCNPMVLQRCTRLPEKFPVTDEMVQAALPGELLTLQEELENGNIFVADYDLLDGIPNAKIDCGHQQYLAAPICLLKYNAQNKLPMIAIQLQNQPGPENPIFLPTDSDYDWLLAKTWVRNSDFQLHQQITHLLRTHLIAEVFAVAMMRQLPCLHPVFKLLIPHFRYTMEINITARQTLLNEGGVFDNVTGGVGGMVLLQTVKSMTYDSICLPDEILGLPATFYYRDDGLRLWEAIEKFVTDVISVFYYSSDVVVADEDLQSWIEDICDVFGMKEGAKGFPKLCRSRELLEFCVTMIFTCASQHAAVNTGQLDYWSWMPNAPTMTRPPPPTTKGVTLEDITDLLDPMARNCMHCMVLSWLLCKQDQLMRTGLFPEHEFEEPKQKPDEMAREFRKRLDDITTAISRNREKNKLPYYYLPDSRLISVENI

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	76.1
NLMSIM	60.0
AACOMP	93.3
Seqdif (SeqID)	48.0 (XP_005153951.1)
Structdif (F-Target)	7.2 (4qwt B)

ProtNLM

Name	Score
Arachidonate 5-lipoxygenase	0.461
Arachidonate 12-lipoxygenase, 12R-type	0.093
Arachidonate 5-lipoxygenase-like	0.092
Arachidonate 12-lipoxygenase, 12S-type	0.047
Arachidonate 12-lipoxygenase, 12R type	0.032
Arachidonate 5-lipoxygenase a	0.023