MZ1VP

Prompt

1.6.5.6

Oxidoreductases. Acting on NADH or NADPH. With a quinone or similar compound as acceptor. p-benzoquinone reductase (NADPH).

AI Generated Sequence

293 AAs
MLLTFAVVVGGGYTGVEAAGELADYVKNDAVKGFPNIVLDNVSVTLIEAGERILAMYDESISKYAEKEFKKRGVHILTGMRVVEVTADGVVTKKGKEIPYGMVVWSAGVAAPFVMKDLGELGTQNRGRVLVEDPWLRTCGDVKYVGDYGLVAVGAQSNTFGTPGVAEHCFKLSEVADAQKIREKILENFEKASLPTTDEEKRRWLSFCIVGGGATGVELAGELIDFVKRSAVRGFPKIVDFVTVTLVEAGERILAMFDERISKYAEEQFKKRGVDVLTGSMVTKVTEDGVFTK

Ligand/Cofactor

NADH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O

Validation Metrics

PLDDT83.1
NLMSIM70.0
AACOMP89.6
Seqdif (SeqID)41.9 (KAI3988178.1)
Structdif (F-Target)40.9 (5yjw 2)

ProtNLM

NameScore
Pyr_redox_2 domain-containing protein0.491
NADH dehydrogenase0.102
Pyridine nucleotide-disulfide oxidoreductase0.081
FAD-dependent pyridine nucleotide-disulfide oxidoreductase0.053
NAD(P)/FAD-dependent oxidoreductase0.048
FAD-dependent oxidoreductase0.035
Designed by MP, using an AMD MI250 GPU