MZ0QW

Prompt

1.1.1.436

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. lactate dehydrogenase (NAD(+),ferredoxin).

AI Generated Sequence

671 AAs

MATKEKLISHVAHEEPVGPRNKVTVVGVGMVGMACAISILLKDLCDELALVDVMEDKLKGEVMDLQHGSLFLKTHKIVSDKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCIMLVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHLMGEKLHLHPSSCHGWIVGEHGDSSVPVWSGVNVAGVSLQELHPELGTDGDKENWKAVHKMVVDGAYEVIKLKGYTSWAIGLSVADLVESIIKNLHRVTPVSTMVKGMHGVKEDVFLSVPCVLGQSGLTDVIQMTLKPEEEKQLVKSAETLWGVQKELTLDKLIAQGKDQILAKEVLKNIPKTSSSKITVVGVGNVGMACAISILLKDGLCDELALVDVNEDKLKGEVMDLQHGSLFLRTPKIVGSKDYSVTANSKIVVITAGVRQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCIILVVSNPVDILTYVAWKLSGFPKHRVIGSGTNLDSARFRYLMGEKLHVHPSSCHGWIVGEHGDSSVPVWSGVNVAGVSLQELNPALGTDGDKENWKDVHKMVVDGAYEVIKLKGYTSWAIGLSVADLVESIMKNLHRVTPVSILVQGMHGIEKDVFLSVPCVLGASGLTDVVHQTLKPEEEKQLKKSAETLWGVQKELTDL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	83.8
NLMSIM	85.0
AACOMP	90.4
Seqdif (SeqID)	28.5 (KAG8524221.1)
Structdif (F-Target)	3.4 (6bb1 D)

ProtNLM

Name	Score
1.1.1.27	0.497
L-lactate dehydrogenase	0.388
LDH-A	0.034
L-lactate dehydrogenase A chain	0.019
LDHA dehydrogenase	0.011
LDH-B	0.008