MYJC6

Prompt

1.1.1.78

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. methylglyoxal reductase (NADH).

AI Generated Sequence

462 AAs

MKKILVLGAGGLGALALAKYLKKKGYKVTVVDPKNYHLFETPLHYAETGTIEGRAIAEFPIRGLLPKKDVFFKTAWVTDVDLEKKVVALKDGTELDYDYLVIALGSIHTPFHTPGVKENAFKLDTIEDAIKINKHILDAFELAELTGDEETRKRLINFSVVGGGLTGVELAGELKDHLEEDLKYLPKLLDCKVTLIEAPRILPAFDKKISEYAEENLTKMGVEVLTTSMVKKVDKNYVTLKDGKEIPYGTVIWATGVKAPRITKELDLEVDKNRILKTDEHLQVKGHDNIFAIGDCCSVVPDGKFPPATQPVAMQAGYLAGKNIKKLEGKETKPFKYKDKGSLASIGRKYGVAELGMPVKGKFAKFLWKAVYYMKYLSFRNKLYVLLDWAKTFLFGKDISRIIDPRNAKLHLGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	83.0
NLMSIM	60.0
AACOMP	85.6
Seqdif (SeqID)	59.7 (MBI4546671.1)
Structdif (F-Target)	8.9 (5na1 A)

ProtNLM

Name	Score
NAD(P)/FAD-dependent oxidoreductase	0.365
NADH dehydrogenase	0.148
Pyr_redox_2 domain-containing protein	0.086
FAD-dependent oxidoreductase	0.077
1.6.99.3	0.073
Pyridine nucleotide-disulfide oxidoreductase	0.064