MYIRN

Prompt

1.3.1.3

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. Delta(4)-3-oxosteroid 5beta-reductase.

AI Generated Sequence

323 AAs

MASNSHRVPLSNGHSMPILGFGTYAQSPKPGTVLESVKLAIDVGYRHIDGAYVYQNEHEIGQAIQERIAEGTVKREDIFYCSKLWNTCHHPELVRPALEKTLKNLQLDYVDLYLIHFPMAFKPGDALFPKDENGKYIYSETDLCATWEAMEACKDAGLVKSIGVSNFNHRQLEMILNKPGLKYKPVSNQVECHPYLTQPKLLEYCQSKDIVVTAYSPLGSPRDPAWVNVDSPPLLEDPVLKNIAKKHNKTAAQVALRFNVQRGVVVIPKSVNEHRIQENFQIFDFQLSEEDMKDIEALNKNWRYVELDMWSDHPDYPFPFEEY

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	90.9
NLMSIM	75.0
AACOMP	92.9
Seqdif (SeqID)	22.6 (XP_014792956.1)
Structdif (F-Target)	2.0 (2fvl C)

ProtNLM

Name	Score
Aldo_ket_red domain-containing protein	0.487
Aldo-keto reductase family 1 member D1	0.025
Aldo-keto reductase family 1 member C3	0.023
3-oxo-5-beta-steroid 4-dehydrogenase	0.020
Aldo-keto reductase family 1 member C1	0.019
Aldo-keto reductase family 1 member C1 homolog	0.018