MY5FY

Prompt

2.3.1.161

Transferases. Acyltransferases. Transferring groups other than amino-acyl groups. lovastatin nonaketide synthase.

AI Generated Sequence

499 AAs
MAAVALPAEEVAALLAGYGRGRPAARPLLLGSVKSNIGHTEAAAGVAGLIKTVLALRHGVLPPSLHFDRPSPRVDWAAGAVRLPTEARPWPATGRPRRAGVSSFGFGGTNAHVILEEAPAPAPAPAPAPAPAVPWVLSARTAAALAAQAARLAAWLAAHPDLALADVGFSLATGRAALAHRAVVVAADRAALAAGLAALAAGEPAPGVVTGVAAAPGRTAFVFSGQGSQWAGMGRELYAAEPVFAAALDACAAALAPHLGWSLRDVLFGDAAALDRTAFVQPALFAVEVALARLWRSWGVRPDAVVGHSLGEIAAAHVAGVLSLPDAARLVAARSRLMQALPGRGAMAAVALPEAEVAARLAGLAGRVSVAAVNGPASTVLSGDAAAVAAVAARLAAEGVRARRLAVDHAFHSPLMDPMLAELRAVAAGLAYRPPRIPVYSNVTGALAAPAELDAAYWVRHLREPVRFADGVAALAADGVATFLEVGPHPVLTHSIAET

Ligand/Cofactor

NADPH

C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O

Validation Metrics

PLDDT94.5
NLMSIM65.0
AACOMP80.2
Seqdif (SeqID)40.0 (WP_256656265.1)
Structdif (F-Target)15.1 (6iyr A)

ProtNLM

NameScore
Carrier domain-containing protein0.154
SDR family NAD(P)-dependent oxidoreductase0.128
Acyltransferase domain-containing protein0.092
Type I polyketide synthase0.091
Polyketide synthase0.072
Beta-ketoacyl synthase0.067
Designed by MP, using an AMD MI250 GPU