MXP50

Prompt

1.2.1.18

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. malonate-semialdehyde dehydrogenase (acetylating).

AI Generated Sequence

499 AAs

MAAPTKLFIDGKFVESKTTDWIDIHNPATQNVIGRVPQATKAEMEAAVASAKAAFPAWADTSIMTRQRIMFKLQALIRENMDKIAKSITLEQGKTLPDAHGDVLRGLQVVEHACSIPTLQMGETVPNVAKDMDTYSYRQPLGVCAGICPFNFPAMIPLWMIPMAIACGNTFVLKPSERVPGATMLLAELCQEAGCPDGVLNIVHGGHDAVNFICDHPDIKAISFVGSDQAGKYIYERGSANGKRVQANMGAKNHCVIMPDANKDATLNQLAGAAFGAAGQRCMALSTAVFVGEAKDWLPELVERAKALKVNAGDEPGADLGPVISKQAKERICGLIDSGVKEGATILLDGRNIKVKGYEKGNFVGPTIISNVKTNMTCYKEEIFGPVLVVMEVDTLDEAIAIVNANEYGNGTAIFTRSGATARKFTHEIEVGQVGINVPIPVPLPFFSFTGNKRSFLGDTHFYGKQGIQFYTQTKTVTQLWRSEDAVKLGASVAMPTMG

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	95.3
NLMSIM	70.0
AACOMP	93.3
Seqdif (SeqID)	23.2 (KAF6391206.1)
Structdif (F-Target)	2.0 (1t90 D)

ProtNLM

Name	Score
1.2.1.27	0.291
1.2.1.18	0.290
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.287
Aldedh domain-containing protein	0.027
Aldehyde dehydrogenase 6 family member A1	0.018
MMSDH	0.010