MXM4K

Prompt

1.1.1.88

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. hydroxymethylglutaryl-CoA reductase.

AI Generated Sequence

425 AAs
MTDSRIPGFRYLSVAERLAALAERAGLTDEERALLAGPGALPLAVADGMIENVIGTFELPLGLATNFLVNGRDVLVPMAVEEPSVVAAASYMARLARDCGGFTASSTEPLMRAQVQVVGVADPHGARLAILAAKDEILALANARDPILVKLGGGCRDIEVHVFPTPRGPMLVVHLLVDVRDAMGANTVNTMAEAVAPLVERITGGTVRLRILSNLADLRLARARVRIPTEVLATREYSGEEVVDGILDAYAFAAADPYRAATHNKGIMNGIDPVVLATGNDWRAVEAGAHAYAARSGRYTSLTTWEKDADGNLVGTIEMPMPVGLVGGATKTHPLARLALKILGVQSAQELAEVAVAVGLAQNMAALRALATEGIQRGHMALHARNIALAAGATGAEIDWVAARMVAEKDVRTDRARELLAELRA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT90.9
NLMSIM70.0
AACOMP88.7
Seqdif (SeqID)19.7 (MDF2861078.1)
Structdif (F-Target)4.5 (4i4b A)

ProtNLM

NameScore
HMG-CoA reductase0.394
1.1.1.880.310
3-hydroxy-3-methylglutaryl coenzyme A reductase0.266
Hydroxymethylglutaryl-CoA reductase, degradative0.019
1.1.1.340.003
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase0.001
Designed by MP, using an AMD MI250 GPU