MXHXD

Prompt

1.14.18.2

Oxidoreductases. Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2. With another compound as one donor, and incorporation of one atom of oxygen. CMP-N-acetylneuraminate monooxygenase.

AI Generated Sequence

588 AAs

MSQEKTTEVLLSLSPVEVASLKEGINAFRNKSTGKEYILYKNKSKLRACKNMCKHQGGLFIKDIEDLDGRSVRCTKHNWKLDVSTMKYINPPGSFCQDELVVEMDEENGLLLLELNPPNPWDSEPRSPEELAFGEVQITYLTHACMDLKLGDKRMVFDPWLIGPAFARGWCLHDEEPSDWLERLCKADLIYISHMHSDHLSYPTLKKLAERRPDIPIYVGNTERPVFWNLNPSGVQLTNINIVPFGIWQQVDKNLRFMILMDGVHPEMDTCIIVEYKGHKILNTVDCTRPNGGRLPRKVALMMSDFAGGASGFPMTFNGGKFTEEWKAQFIKAERKKLLNYKAKLVKDLQPRIYCPFAGYFVESHPSDKYIKETNTKNDPNELNNLIRKNSDVVTWTPRPGATLDLGRMLKDPTSDKSIIEPPEGTKIYKSDWDFAPYLNILNAVDGEIFHESSWIKEYFTWFAFKDYNLVVRMIETDEDFNPFPGGYDYLVDFLDLSFPKERSPREHPYEEIYRSVDMVRHVVKNGLLWDDLYIGFQTRLQRDPDVYDHHFWNHFQIKLPLTSPPNWKSFLCHCENTTNTTCVSQET

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	72.3
NLMSIM	95.0
AACOMP	91.9
Seqdif (SeqID)	9.9 (XP_012364585.1)
Structdif (F-Target)	15.7 (6hrg A)

ProtNLM

Name	Score
CMP-N-acetylneuraminate monooxygenase	0.373
CMP-NeuAc hydroxylase	0.185
Cytidine monophosphate-N-acetylneuraminic acid hydroxylase	0.181
CMP-Neu5Ac hydroxylase	0.141
1.14.18.2	0.069
CMP-N-acetylneuraminic acid hydroxylase	0.003