MWWUP

Prompt

1.3.1.91

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. tRNA-dihydrouridine(20) synthase [NAD(P)(+)].

AI Generated Sequence

328 AAs

MKKLKLSVAPMIDWTDRHCRFFHRLLSKHALLYTEMVTTGAIIHGDKDRLLAFDEVEHPVALQLGGSDPADLAQCAKIGEEFGYDEINLNVGCPSDRVQNGRFGACLMKEPALVADCVKAMADVVSIPVTVKCRIGIDDQDSYEVLCDFIGTVAEAGCETFIVHARKAWLKGLSPKENREIPPLKYDRVYQLKQRFPHLTISINGGIKSLEEAKAHLQHVDGVMIGRAAYQNPYILAAVDREIFGTDTPVDRREAVLRAMLPYIERHLSGGTKLHAMTRHMLGLFQGMPGARQWRQVLSENAHKPGAGIEVLEQALAKVDYKTLGVAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	92.8
NLMSIM	90.0
AACOMP	95.1
Seqdif (SeqID)	24.8 (EJL6553492.1)
Structdif (F-Target)	2.0 (3b0u Y)

ProtNLM

Name	Score
1.3.1.91	0.267
TRNA-dihydrouridine synthase A	0.225
U20-specific Dus	0.191
TRNA-dihydrouridine(20/20a) synthase	0.191
U20-specific dihydrouridine synthase	0.111
TRNA dihydrouridine(20/20a) synthase DusA	0.004