MWP65

Prompt

6.2.1.54

Ligases. Forming carbon-sulfur bonds. Acid--thiol ligases. D-alanine--[D-alanyl-carrier protein] ligase.

AI Generated Sequence

498 AAs

MKSLIDAIDAFARETPDTPAYVWRGETLTYGQLKADSDALAHWLSAELPADRSPIMVFGGHMPEMIACFLGCVKAGHAYIPVDLSIPADRVARIAEASGAKLILNAADLPVTDLPVISVENLKDAIFAEHKLDPAPAHAVKGDENFYIIYTSGSTGNPKGVQITHNNLVSFTKWLVDDFNLQTGQVFLNQAPFSFDLSVMDIYPSLASGGTLCAIDKAMIADFKDLFAALPQSPLQVWVSTPSFMDLCLLEPAFSAENYPRLRMFLFCGEVLPHETARKLIERFPKARILNTYGPTEATVAVTQIKVTDEVLDQYKSLPVGYCKPDMRLILMDENGEALPEGRKGEIVIVGPSVSKGYLGNPELTKEAFFTYDGERAYRTGDAGFVEDGMLFYNGRLDFQIKLHGYRMELEEIEHHLRAVPYVSEAVVVPIVKDGKHDYLLAAVVPEHEFKLTSAIKKELRARLMPYMIPRKFVYQSSFPLTANGKVDRKKLLGEVTA

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT	83.4
NLMSIM	70.0
AACOMP	95.9
Seqdif (SeqID)	25.9 (PFE23548.1)
Structdif (F-Target)	5.2 (3fce A)

ProtNLM

Name	Score
D-alanine--D-alanyl carrier protein ligase	0.248
D-alanine--poly(phosphoribitol) ligase subunit 1	0.215
D-alanine-activating enzyme	0.200
DAE	0.130
6.2.1.54	0.112
DCL	0.075