MWMPO

Prompt

2.3.3.13

Transferases. Acyltransferases. Acyl groups converted into alkyl groups on transfer. 2-isopropylmalate synthase.

AI Generated Sequence

277 AAs
MLKNASTKYAPFTPVQLPDRTWPNATITRAPIWLSTDLRDGNQALIDPMSVEQKLRFFDLLVKIGFKEIEVGFPSASQTEFDFVRKLVEDTRIPDDVTIQVLTQAREDLIRRTFESVKGAKHAIVHLYNSTSAFRRRVVFNMSKEGIKDIAVAGTKLIKEYAEQQPDTQWHFEYSPSTFSTAEVDYAVEVCNAVMDIWQPTDAHKAVLNLPAVECASTPNVYADQIEWMGHNFHHRDSVILSLHTHNDRGGAVAAELEGLQAGADRVEGCLFGNGER

Ligand/Cofactor

acetyl-CoA

CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O

Validation Metrics

PLDDT90.8
NLMSIM85.0
AACOMP95.2
Seqdif (SeqID)32.5 (PZN02113.1)
Structdif (F-Target)5.3 (3u6w A)

ProtNLM

NameScore
2-isopropylmalate synthase0.589
2.3.3.130.323
Pyruvate carboxyltransferase domain-containing protein0.064
Alpha-isopropylmalate synthase0.006
Alpha-IPM synthase0.004
Isopropylmalate/homocitrate/citramalate synthase0.001
Designed by MP, using an AMD MI250 GPU