MWE3T

Prompt

1.1.1.262

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 4-hydroxythreonine-4-phosphate dehydrogenase.

AI Generated Sequence

329 AAs

MTKKLAITPGDPAGIGPEIILKALHEREEACPVVVIADAHLLKERAKLLGLPLNLIEYSPHNPAQPQRAGTLTVLPVPLAAPVIAGQLDPVNGAYVVETLERACGGCLSGDFAAMVTGPVHKGVINRAGIPFSGHTEFFADRSGTKRVVMMLATGGLRVALVTTHLPLADIADAITRDLLEKVIAILHHDLRTKFGIARPRILVCGLNPHAGEGGHLGTEEIDVIIPTLDQLRGEGMDLSGPLPADTLFQPKYLEHADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRVSVDHGTAYDLAGSGKADVGSLITALKLAYQMVENRTL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	94.6
NLMSIM	90.0
AACOMP	92.3
Seqdif (SeqID)	24.6 (WP_105272905.1)
Structdif (F-Target)	1.9 (1ps6 A)

ProtNLM

Name	Score
4-hydroxythreonine-4-phosphate dehydrogenase	0.381
1.1.1.262	0.341
4-(phosphohydroxy)-L-threonine dehydrogenase	0.270
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase	0.001
HMBPP reductase	0.000
4-hydroxythreonine-4-phosphate dehydrogenase PdxA	0.000