MWDQA

Prompt

1.3.1.3

Oxidoreductases. Acting on the CH-CH group of donors. With NAD(+) or NADP(+) as acceptor. Delta(4)-3-oxosteroid 5beta-reductase.

AI Generated Sequence

379 AAs

MATNHIVPLNDGHSMPILGFGTYAASKPVTKGSVLEAVKVAIDAGYRHIDCAYVYQNEHEVGQAIQEKIAEGTVKREDIFYCGKLWNTCHKPELVRPALEKTLKDLQLDYVDLYLIHFPMAFKPGDELFPKDENGKYIYSETDLCATWEAMEECVDAGLVKSIGVSNFNRRQLEMILNKPGLKYKPVSNQVECHPYLTQPKLLEYCQSKDIVVTAYSPLGTPRDPAWVNVDSPPLLEDPVLKAIAKKHNKTAAQVLIRFNVQRGVVVIPKSVNPERIQENFQIFDFQLTEEEMKDIEALNKNWRYVELLIWSDHPDYPFHDEYEDEPIELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	92.3
NLMSIM	65.0
AACOMP	86.9
Seqdif (SeqID)	20.8 (XP_054137928.1)
Structdif (F-Target)	1.4 (3gug A)

ProtNLM

Name	Score
Aldo_ket_red domain-containing protein	0.658
Aldo-keto reductase family 1 member D1	0.073
Aldo-keto reductase family 1 member B1	0.017
Aldo-keto reductase family 1 member B7	0.014
Aldo-keto reductase family 1, member D1	0.009
Aldo-keto reductase family 1 member B10	0.008