MWBRU

Prompt

6.3.2.2

Ligases. Forming carbon-nitrogen bonds. Acid--amino-acid ligases.(peptide synthases). glutamate--cysteine ligase.

AI Generated Sequence

527 AAs
MKKLLKKRLAELSDAGHRELLKGIRLGIERETLRVDTDGRLAQTPHPEALGSALTHPYITTDYSEALLEFITPVPEDAGAALAQLDALHRFAYAKLGDEYLWPLSMPCPLPAEDDIPIAQYGTSHIGRMKTVYREGLALRYGRAMQCISGIHYNFSLPEALWPLLQQIEGEAGDRAAFRSAGYLALARNLRRYSWLLTYLFGASPALDAGFLRGREHQLEQLDADTLYLPYATSLRMSDLGYQNDAQAGLTPCYNDLASYVASLRKAVETPYPAYVAVGAHRDGEWVQLNTGILQIENEYYSTIRPKRVTYSGERPIQALVARGVQYVEVRCLDLNPFLPTGIDAETLRFLDAFLLYCALNDSPLLDGAECGNANANLLTVAKEGRRPGLQLQRAGQPVTLADWAAELLAQIGPLARLLDQSHGGDAHLQALAAQQAKVADPALTPSAQVLAAMRDHGESFAAFSLRQSRAHAEHFRARPLAAETQAAFEALAERSLAEQAELEATDTVSFDDFVGAYRASILANSH

Ligand/Cofactor

ATP

C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

Validation Metrics

PLDDT85.5
NLMSIM85.0
AACOMP90.8
Seqdif (SeqID)25.6 (WP_025110984.1)
Structdif (F-Target)7.1 (2d33 C)

ProtNLM

NameScore
Gamma-glutamylcysteine synthetase0.231
GCS0.220
Gamma-ECS0.213
6.3.2.20.189
Glutamate--cysteine ligase0.139
6.3.2.30.001
Designed by MP, using an AMD MI250 GPU