MW2D3

Prompt

1.2.1.27

Oxidoreductases. Acting on the aldehyde or oxo group of donors. With NAD(+) or NADP(+) as acceptor. methylmalonate-semialdehyde dehydrogenase (CoA acylating).

AI Generated Sequence

289 AAs

MTTIPTLHINGAEVAGESGRFTDVFNPATGEVVGRVPLASAEELDAAVASAEAAFPAWAATPLQRRARVMFRLQELLRENRDRLAAITSREHGKTLADAKGEIFRGLEVVEFACGIPHLLKGEYTDVAGPGIDVYSMRQPLGVCAGITPFNFPAMIPLWMFPLAIACGNAFILKPSERDPSVPLMLAELFKEAGLPDGVLQVVNGDKEAVDAILTHPRIRAVSFVGSTPIAQYIYGRGTENGKRVQAFGGAKNHAIVMPDADLDQTINALIGAGFGAAGERCMAVSTVV

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	95.5
NLMSIM	95.0
AACOMP	92.6
Seqdif (SeqID)	23.6 (WP_210527729.1)
Structdif (F-Target)	4.2 (7kqv 2)

ProtNLM

Name	Score
Methylmalonate-semialdehyde dehydrogenase (CoA acylating)	0.298
Aldehyde dehydrogenase family protein	0.220
CoA-acylating methylmalonate-semialdehyde dehydrogenase	0.212
1.2.1.27	0.097
Methylmalonate-semialdehyde dehydrogenase	0.076
Aldedh domain-containing protein	0.027