MW24D

Prompt

1.13.11.15

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. 3,4-dihydroxyphenylacetate 2,3-dioxygenase.

AI Generated Sequence

280 AAs
MGELVLGAKATHVPSLALAEVPGHADGPCAAALAAYGEIGRRARELGADTVLVLDTHWLVNAAFHANAPQFHIGAYTAPEGFGIRDIQYAYPGNPELARHIAEAALARGMGTRAYAPEMRLELEYGTLVPLRYMCGPDGWKVVSVATAGVLQLQLADCRALGEALRRAVEGSGGRVLVLASGSLSHRFWDDAHGERPDIAWSLNEDVDRRVLALWRDGQFAECLAMLPDYLACFEGEGGHDTALLLGALGLDGRLGRLAHREFYAYSGTGMGNIVFPLAA

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT78.3
NLMSIM90.0
AACOMP88.5
Seqdif (SeqID)50.2 (WP_058910473.1)
Structdif (F-Target)9.4 (8iq8 D)

ProtNLM

NameScore
3,4-dihydroxyphenylacetate 2,3-dioxygenase0.658
1.13.11.150.182
Extradiol ring-cleavage dioxygenase0.028
LigB domain-containing protein0.018
Dioxygenase0.018
Catechol 1,2-dioxygenase0.009
Designed by MP, using an AMD MI250 GPU