MVMU5

Prompt

1.1.1.31

Oxidoreductases. Acting on the CH-OH group of donors. With NAD(+) or NADP(+) as acceptor. 3-hydroxyisobutyrate dehydrogenase.

AI Generated Sequence

301 AAs

MKIGFIGLGNMGAPMARNLLKAGHEVTVFDLSKAAVEALVAEGATVASSPADAAAGAEVVITMLPAAKHVRSVYLGEDGVLAGARKGVPLIDCSTIDPQTARDVAAAAAKHGIEFVDAPVSGGTGGAQAGTLTFMVGASEAAFEKLKPVLEQMGKNIVHCGDVGTGQIAKICNNLILGISMAGVSEAMALGVANGLDTKVLAGIINTSSGRCWSSETYNPWPGVVETAPASRGYTGGFGADLMLKDLGLANEAARKVHQTTPLGALAQQLYQTMSQRGEGGKDFSAIINLYRKGEGLIVKK

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	93.6
NLMSIM	75.0
AACOMP	90.6
Seqdif (SeqID)	21.5 (WP_032862808.1)
Structdif (F-Target)	3.2 (3q3c A)

ProtNLM

Name	Score
HIBADH	0.414
1.1.1.31	0.342
3-hydroxyisobutyrate dehydrogenase	0.238
1.1.1.387	0.001
Malate dehydrogenase	0.000
HMG-CoA reductase	0.000