MV2DA

Prompt

1.13.11.34

Oxidoreductases. Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2. With incorporation of two atoms of oxygen. arachidonate 5-lipoxygenase.

AI Generated Sequence

500 AAs

MPNYTVTVTGSQWFAGTDDYVYLSLVGQRGCSEKQLLDKPFYNDFERGAVEDYTVQVDEELGDILLVKLEKRKYLWDDDWYCNYITVKTPTGDYVEFPCYRWITGDKEVVLREGRAKTPGQDTQNILKQHRRQELEGQKQFYRWESWIPGFPLSIDACHLDDLPIDDQFDENKGVDFTLNSAKALEYINRFQHLMQSSWNDRDDFDKIFGVKSNTLSEYVMHQWREDEFFGYQFLNGCNPMLIRRCTELPEKLPVTPDMVERSLEEGNTLEQELQRGNIFLADYELLDGIVANKTDGTCQQYLAAPLCLLKYNLANGKLPMAIQLQQPPGPEPNPIFLPSDSAYDWLLAKIWVRSSDFHVHQITTHLLRTHLVAEVFCVAAMRQLPAVHPVFKLLVPHFHYTMSINTIARTELICEGGLFDKVNSTGGGHVQLVRRALDTLTYSSLCFPEEIGRDLPNFYYARDGLRLWDAIKSFVTEVIEHYYKSDEVVQRDPELQSWC

Ligand/Cofactor

NAD(+)

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

Validation Metrics

PLDDT	87.7
NLMSIM	95.0
AACOMP	93.1
Seqdif (SeqID)	32.4 (XP_042643578.1)
Structdif (F-Target)	6.5 (3v92 B)

ProtNLM

Name	Score
Arachidonate 5-lipoxygenase	0.481
Arachidonate 5-lipoxygenase-like	0.081
ALOX12	0.043
LOX5 lipoxygenase	0.042
ALOX5	0.036
Polyunsaturated fatty acid lipoxygenase ALOX12	0.026